Friday, January 31, 2020

Sherlock Holmes stories Essay Example for Free

Sherlock Holmes stories Essay Can the continued popularity of the Sherlock Holmes stories be explained by the similarity to modern television detectives? Discuss this statement with reference to The Speckled Band. The Sherlock Holmes saga has a huge inspirational impact on todays television detective stories. The reason why the Sherlock Holmes mysteries are so successful is because they contain many qualities of a classic mystery genre. It is a fair presumption if one was to say that the stories always follow a certain pattern and that in normal circumstances it is expected of the reader to lose interest, but Sherlock managed to obtain his popularity even to present day. A clear sign of how cleverly crafted Arthur Conan Doyle made these crime stories. Sherlock Holmes is a crime detective who has the ability to solve the hardest of criminal equations with the minimalist of facts, using his somewhat superb observational skills and his incredible method of scientific deduction. There is no mystery, my dear madam, said he, smiling. The left arm of your jacket is spattered with mud in no less than seven places. The marks are perfectly fresh. There is no vehicle save a dog-cart which throws up mud in that way, and then only when you sit on the left-hand side of the driver. Quoted from The Speckled Band. Holmes is a realistic and believable character, bringing the novels to life. Holmes always inspires a sense of confidence in other characters and indeed the reader as he shares a certainty of his attitude towards the mystery and the way he doesnt suffer fools gladly, always using his own initiative. This makes the reader feel as if Holmes is very confident about himself, thus making the reader confident and ultimately it makes them read on, a perfect example of Arthur Conan Doyles ability to captivate his readers. Always accompanying Holmes was his loyal companion and entrusted sidekick Dr Watson. With his old fashioned values and his consistent reliability, Watson is the perfect partner for Holmes. Watson shows a sense of amazement towards Holmess abilities and although he explains his deductions and predictions, Watson still could not do it himself. In terms of solving the crime, Watson seems rather useless. And as most of the time it seems as if Watson does not know whats going on inside Sherlocks mind, this adds suspense to the story. Arthur Conan Doyle has cleverly used Watson as a tool Holmes explains his methods and deductions to Watson and therefore to the reader. Watson is also the narrator of the story. Holmes appears in four novels and fifty-seven short stories. Arthur Conan Doyle got tired of writing about Holmes and so he killed him off in 1893 by having him fall to his death over the Reichenbach Falls in Switzerland. The stories had stop in production over one hundred years ago but still to this day they are very successful. Sherlock Holmes was modeled on and originated from Dr Joseph Bell, a surgeon in Edinburgh who had an extraordinary ability to deduce the backgrounds and occupations of his patients from minute details of their appearance. An excellent example of how the Sherlock Holmes saga has influenced modern crime story structures is Inspector Morse, a recently finished epic of mystery/crime television programs. Spanning 14 years, the ever-popular series shared a certain similarity to Holmes. Written by Colin Dexter and starring John Thaw (Left) as Inspector Morse and Kevin Whately as his trusted side kick Lewis (Right), Inspector Morse captivated viewers of all ages and class, again, very similar to Holmes. Morse and Lewis appear in thirty-three episodes and the stories are also available in other formats, such as paperback novels, paperback omnibuss and audio books as are the Holmes stories. Here is a description of the Speckled Band, one of the many successful Holmes stories written by Arthur Conan Doyle, and Deadly Slumber one of the thirty-three stories written by Colin Dexter, purposely to give a clear contrast of the similarities,: Deadly Slumber When Dr. Brewster is found dead in his car in his locked garage, everyone but Chief Inspector Morse writes the doctors death off as a suicide. A comment by the doctors wife troubles Morse, and he thinks the good doctors death anything but suicide. The chief inspectors suspicions are quickly confirmed by the autopsy it was murder. His investigation of the family soon uncovers a grudge against the family after a botched surgery on the daughter of Michael Steppings, a millionaire businessman who became a semi-reclusive following his daughter Avrils surgery that left her in a vegetative state. Steppings vowed to avenge his daughters condition on all parties involved in the surgery after losing a civil suit against the doctor and his clinic. Steppings goes so far as to send threatening letters to the doctor, but not the two other people on the surgical team the day of the operation. This oversight puzzles Morse. Steppings becomes Morses prime suspect and just as quickly is cleared by Morse and Sgt. Lewis. Then Morse is pointed in one direction by the family and another by his former prime suspect in Daniel Boyles extremely well crafted script. The last twenty minutes of Deadly Slumber is a roller coaster ride as the evidence leads Morse to one suspect after another. The adventure of the Speckled Band The speckled band leaves Helen Stoners twin sister in a state of occult horror just before her marriage. Now its Helens marriage and the same whistling sounds that her sister had heard in the nights preceding her death have come back to Stoke Moran. Her estranged stepfather seems to be the only culprit as the only other inhabitants of the old English stately home are the wild baboon and leopard. Holmes and Watson are quickly on the case, and come to the strange conclusion that it was a rare and highly venomous snake that was to blame for the mysterious deaths. As you can see both stories share the same basic structure, with the build up of suspense and the analysis of the deduction. Though perhaps one might say that the endings of the Holmes stories were somewhat more imaginative and dramatic in comparison to Morses more down to earth, realistic conclusions. To conclude, the continued popularity of the Sherlock Holmes stories, in my opinion, can be explained by the similarity to modern television detectives, as the modern television detectives are too similar to Holmes to dismiss as being created from a different origin. Taking into account the Sherlock Holmes stories were created over one hundred years ago it is fair to presume that modern day crime/mystery authors get there inspirations from the likes of Arthur Conan Doyle.

Thursday, January 23, 2020

Definitions of Self in Community in Morrisons Sula and Song of Solomon

Definitions of Self In Community in Sula and Song of Solomon        Ã‚  Ã‚   "In that place, where they tore the nightshade and blackberry patches from their roots to make room for the Medallion City Golf Course, there once was a neighborhood" (Sula 1). Toni Morrison begins the novel Sula with these powerful words, describing more than a physical place, but a spiritual place where a community once stood. She begins with the destruction of the community, ultimately beginning at the end because her novel traces the history of this community. In Song of Solomon. Morrison takes the opposite path. She traces the history of self that ultimately ends in a type of destruction when Milkman leaps off the cliff. In both novels, however, she explores the tension between self and community and the sacrifices each demand from the other. Morrison's characters are both empowered and restricted by the heavy sense of community that operates in her novels. In all of her novels the characters are pulled along by and enmeshed in the communities in which they live. In Sula and Song of Solomon the struggles of me community and me characters with in the framework of community are me driving force behind much of me novel. Both the characters and the larger communities are irrevocably changed throughout me course of the novels the as tension to define both individual and community surfaces. From the opening lines of Sula which foreshadows me ultimate deem of me community, Morrison calls attention to me sense of community in the Bottom. In "Eruptions of Funk. Susan Willis says, "The opening line from Sula might as well have been me novel's conclusion, so complete is the destructioni it describes. This is the community Morrison is writing to reclaim" (315)... ... Pessoni, Michele. â€Å"‘She was laughing at their God.’: Discovering the Goddess Within Sula.† African American Review 29 (1995): 439-451. Rigney, Barbara Hill. The Voices of Toni Morrison. Columbus: Ohio State University Press, 1991. Rubenstein, Roberta. â€Å"Pariahs and Community.† Toni Morrison: Critical Perspectives Past and Present. Ed. Henry Louis Gates, Jr. and K. A. Appiah. New York: Amistad Press, Inc., 1993. 126-1 58. Smith, Valerie. â€Å"Song of Solomon: Continuities of Community.† Toni Morrison: Critical Perspectives Past and Present. Ed. Henry Louis Gates, Jr. and K. A. Appiah. New York: Amistad Press, Inc., 1993. 274-283. Willis, Susan. â€Å"Eruptions of Funk: Historicizing Toni Morrison.† Toni Morrison : Critical Perspectives Past and Present. Ed. Henry Louis Gates, Jr. and K.A. Appiah. New York: Amistad Press, Inc., 1993. 308-329.      

Tuesday, January 14, 2020

Human Embryonic Kidney Cells

In figure A: Human embryonic kidney cells were transfected with constructs for carrying out this experiment. Immuno-precipitation was carried out of tagged PAG with an antibody against regulator Myc, its interaction is studied here with SRC & BRK follwed by immunoblotting analyzation. The result of this experiment was delaying in electrophorectic mobility of tagged PAG protein, when it was co-expressed with SRC. This delay is considered due to hyper-phosphorylation. However, on co-expression of PAG and BRK this band shift was less evident. In figure C: Co-transfection of HEK 293 cells with MYC-PAG and SRC followed by treatment in the absence or presence of SRC kinase inhibitor SU6656 (5 M) for atleast 1 h. PAG was immunoprecipitated by antibody against MYC, and the binding of CSK was compared by immunoblotting. The disturbance of link b/w CSK and PAG was observed on weakening SRC activity by a small molecular inhibitor SU6656, this experiment illustrated the importance of SRC kinase activity for functioning of CSK. B) to test the same hypothesis with controls, take breast cancer frozen samples of different patients, divide the sample in two groups one will be the test group other the control group. The control group will be given doses of anti tumor medication (say tamoxifen for breast cancer). RNA will be extracted from both groups using trizol and will be followed by purification assay. The breast cancer cell lines will be transfected with empty vectors or pcDNA3-MKP3-V5. Further the transfectants will be placed in media MEM along with phenol red. Followed by SDS PAGE electrophoresis, and transfer to nitrocellulose membrane. After transferring they will be incubated with primary antibody for an hour or above then with secondary antibody to observe the chemiluminescence with a reagent. The cells will then be lysed in a buffer, phosphatase reaction carried out will be observed via assays and transfected cells will be compared with control ones to whom tamoxifen was given.

Monday, January 6, 2020

Product Design Process - MS - Free Essay Example

Sample details Pages: 7 Words: 2065 Downloads: 9 Date added: 2017/06/26 Category Uncategorized Essay Type Narrative essay Did you like this example? 1 EXECUTIVE SUMMARY In this report, overall definition of product design process is discussed through analyzing the design process, which Marks and Spencer clothing business unit is employing. I have also thrown light on Performance Objectives of Mark and Spencer which encompass quality, speed, dependability, flexibility and cost within the product design process. The report demonstrates how in highly unstable and neck to neck competitive business environment of the fashion industry, how rapid access to market and cost reduction approach is essential to survive. Don’t waste time! Our writers will create an original "Product Design Process MS" essay for you Create order The report outlines that how MS line up their design process by means of implementing a cost engineering strategy for alleviating waste level and render improvement in their recycling process. Furthermore, this report illustrates that how retailer maintain close relationships with their suppliers and so builds a strong supply chain in order to reduce their manufacturing and material costs and to shorten their access time to market. Furthermore, this report demonstrates how MS meet up the needs of individual target customer groups by offering them order-winning and qualifying factors that are unique for each of their clothing brands. Therefore, the report outlines the criteria which MS considers for identifying their customer segments and their needs regarding the following clothing ranges: à ¢Ã¢â€š ¬Ã…“Classicà ¢Ã¢â€š ¬Ã‚ , Autographà ¢Ã¢â€š ¬Ã‚  and à ¢Ã¢â€š ¬Ã…“Per unaà ¢Ã¢â€š ¬Ã‚ . In the end, it illustrates how each of these clothing ranges are in compliant of a forementioned performance objectives. Any deviation in the performance objectives with those of clothing ranges are explained in the report by means of a polar diagram. The diagram states that the Classic range is of low price but provides higher levels of dependability (read it accessibility) in all their outlets. Autograph and Per una are the products of quality, speed, and dependability. In order to meet the performance objectives, MS has relocated their operations in countries where there is cheap labor available and thus low input jobs. This aids the company manufacture their clothes at lower cost. Moreover, owing to Globalization, the retailer expanded its operations globally to substantiate their profits and thus value-add their customers by the benefits of dependability and speed owing to Mark and Spencerà ¢Ã¢â€š ¬Ã¢â€ž ¢s abrupt production delivery across countries. Contents 1. The Design Stage Process . 3 2. Research techniques .3 3. Performance Objectives 4 4. Quality function deployment 5 5. Value-Cost Engineering 5 6. Consumer Segmentation5 The Design Process A good design not only conform to customersà ¢Ã¢â€š ¬Ã¢â€ž ¢ needs but also communicate the purpose of the product to its market, hence help company reap financial reward out of its products. Marks and Spencer is a company which manufacture their own product at their own manufacturing plant in order to ensure their product quality and durability. Marks and Spencer needs to know about:- CONCEPT; the value of its clothing ranges PACKAGE; products which provide the benefits defined in the concept PROCESS; way products will be manufactured The design stage process is a process which involves following main components:- Transformed resources Technical information Market research Time management Transforming resources: Testing Facilities Staffing Why Marks and Spencer needed Design Stage process? Because while manufacturing their products they need to ensure quality, speed, dependability, flexibility and low cost in order to give their customers a product they want. The transformed resources at Marks and Spencer have undergone vast change because of unstable fashion industry. In order to manufacture competitive products at Marks and Spencer, they need to meet up their performance objectives hence manufacture their products in cognizance of them. Research Techniques Primary Research techniques like Customer Feedback are what, Marks and Spencer hold great significance about. In MS, customers are being provided with enormous number of opportunities to leave feedback about their shopping experience. This mean of primary research is of great benefit for MS because in this way, they get aware of how customer think about MS because customers can give anonymous feedback online and may be more inclined to say how their experience really was. The output of product design process can be measured by: Quality Speed Dependability Flexibility Cost During Credit Crunch, occurred at 2010, Marks Spencer introduced a major market-research program to find out how incline in tax and downfall in capital expenditure will effectuate their customers. This fact is a proponent of their sensitivity towards external factors which may affect their sales. Performance Objectives Due to the industry Marks and Spencer are in, they need to care about what is important to their customers. They need to be aware of what their customers need in each range and what they want from their products. Marks and Spencer Customer Service report states Sustainability hold weightage to our customers but they have other priorities too. They want us to make it easier for them to buy more sustainable products and live more sustainably. Performance Objectives Key Performance Indicators Other Qualifiers Old Winners Speed On time delivery/production Deliver products to store/ direct to customers on time Deliver product before expected date Quality Customer satisfaction Provide high quality goods to customers Introduction of better products for customers Cost Cost comparison Competitive industry cost Value for money Dependability/ Reliability Reliability of product/service Ability to meet orders Fulfil all orders without failure Flexibility Design change To produce and sell to customer demand (color) Produce a wide range of products Quality Function Deployment Quality Function Deployment holds great significance to Marks and Spencer because in this way they would get to know about their customerà ¢Ã¢â€š ¬Ã¢â€ž ¢s needs. QFD while looking at customer requirements and implements these requirements into the product design. This is important to Marks and Spencer because they not only need to know what the customerà ¢Ã¢â€š ¬Ã¢â€ž ¢s needs are but also what customers want. This links with section two order winners and qualifiers because they need to constantly thinking about what they can do to their products to make them desirable. Value-Cost Engineering à ¢Ã¢â€š ¬Ã…“The purpose of value engineering is to try and mitigate costs, and prevent any unnecessary costs, before producing the product or service.à ¢Ã¢â€š ¬Ã‚  Marks and Spencer need to get the quality of the products without the standards slipping. This is important because they need to ensure the material which they use is cheaper but still high quality and think of all the design aspects to the product. When Marks and Spencer consider reducing their costs they must not take away what the customer wants otherwise their products will not sell. This is important with the Classic range because they need to produce products which are for older women and so they need to be easy access and simple designs. This is good for Marks and Spencer because they can keep costs low due to the basic design meaning they can spend more time and money on ensuring quality. Cost Engineering and Concurrent Engineering strategies Cost reduction process is crucial to organizations because lowering cost leads to a manifold increase in gross profit. Although companies consider production costs prior to launching a new product, costs become even more important when organizations get involved in price-based competitions. The cost engineering is a cost reduction strategy which aims on brushing off unnecessary costs without changing quality and liability of the design For instance, MS has recently started spearheading a new project which aims to reduce waste by means of using the recycled unwanted garment to produce new clothes. This strategy not only leads to cost reduction but also increased operation efficiency. Moreover, MS is constantly forging good relations with their suppliers and are strengthening their supply chain. The company is searching for cheaper material to make new clothes. MS also manufactures clothes in countries where labor cost is low. MS also chooses strategically located suppliers so that they could faster distribute products from manufacturing plan ts to stores to shorten Time to Market and save on shipping costs. MS constantly invests in new technologies which leads to the increased production efficiency and helps the company achieve the aforementioned SPEED objective. It is important to use strategies for product innovation in order to reduce Time to Market. Due to frequently changing fashion trends, it is crucial to reduce Time to Market and so the clothing retailers must be able to react to the changing market needs rapidly, effectively and responsibly. Therefore, the concurrent engineering strategy offers rapid solutions to product design and development process. This type of strategy aims to achieve the optimization and distribution of a firms resources in the design and development process to ensure effective and efficient product development process. Costumer Segmentation It refers to classification of groups of individuals based on the chosen criteria relevant to an organizationà ¢Ã¢â€š ¬Ã¢â€ž ¢s marketing activities and so encompass characteristics like customer age, gender, interests, spending and purchase habits. Therefore, in order to sustain intensive competition in the market, organizations ought to conduct a massive market research to capture shifts in their customer needs and preferences. Moreover, companies must attend to socio-cultural changes by developing new products and improving existing products that will satisfy newly emerged customer requirements. MSà ¢Ã¢â€š ¬Ã¢â€ž ¢s three most popular clothing lines Classic, Autograph and Per una are uniquely positioned to adapt to the key operational marketing factors, such as customer segments and their individual needs, quality, design and price, as well as order-winning and qualifying factors. Each of above clothing lines shares several unique characteristics, such as price, quality and design, which satisfy individual needs of different MSà ¢Ã¢â€š ¬Ã¢â€ž ¢s customer segments. Such customer segmentation allows MS to market their clothes to the specific target audience and thus deploy their marketing tactics more effectively. The Classic clothing line is aimed at core MS customers who are both women and men, aged between 35 and 55. The Classic collectionà ¢Ã¢â€š ¬Ã¢â€ž ¢s design is defined through simple and basic clothing, such as sweaters, jeans, white shirts and plains. This clothing line delivers convenience to their customers as the clothes are machine washable, non-iron and tumble-dry friendly. Therefore, such the clothes reflect the target customerà ¢Ã¢â€š ¬Ã¢â€ž ¢s busy lifestyle. Moreover, this clothing range caters to those who look for decent quality and affordable price and therefore appreciate good value for money. The design for this clothing range is timeless and that means that design does not need to be constantly reinvented. Autograph is a seas onal clothing range which brings about spring and summer collections for men and women. It offers formal wear and elegant clothing for upper middle class customers that value luxury upmarket goods and are willing to pay a premium price. This clothing line represents the work of MSà ¢Ã¢â€š ¬Ã¢â€ž ¢s best designers and therefore the clothes are offered at high street prices and are available on selected boutique stores. The purpose of the Autograph clothing line is to bring a cutting-edge design to a wider audience. This clothing range also reflects unique and dynamic seasonal trends and therefore requires adapting to constantly changing socio-cultural environment. Per una is Mark and Spencerà ¢Ã¢â€š ¬Ã¢â€ž ¢s most expensive clothing range if compared with Classic and Autograph clothing lines. Per una clothing line aims to design clothes based on the latest fashion trends and then position the clothes as premium and exclusive. Per una offers the highest quality clothing material and very limited editions. This clothing range captures the target audience of wealthy fashion-conscious women, aged between 25 and 35. The target customer prefers unique and trendy clothes that reflect their high social status and help them stand out from the crowd. A firmà ¢Ã¢â€š ¬Ã¢â€ž ¢s competitive advantage is determined by distinguishing two competitive order-winning and qualifying factors. Order winning factors are those characteristics which directly and significantly contribute to winning business. They are considered by customers as major reasons for getting the products or service: à ¢Ã¢â€š ¬Ã‹Å"raising performance in an order winning factor will either result in more business or improve the chances of gaining more businesses. The qualifiers can be defined as condition of competitiveness where the operationà ¢Ã¢â€š ¬Ã¢â€ž ¢s performance has to be above a specific level to be considered by the customer. For instance, MSà ¢Ã¢â€š ¬Ã¢â€ž ¢s Classic range is known for its hi gh reliability and functionality as the clothes does not wear off after multiple washes. This feature is the clothing lineà ¢Ã¢â€š ¬Ã¢â€ž ¢s order winning factor. Moreover, its qualifying factor is high quality at a reasonable price. MSà ¢Ã¢â€š ¬Ã¢â€ž ¢s Autograph rangeà ¢Ã¢â€š ¬Ã¢â€ž ¢s order-winning factors are high quality and clothing based on seasonal trends.